00280nas a2200109   4500000000100000008004100001100001800042245001700060856007200077300001400149490000700163       1999                            d1 aGeorg Stacher00aIntroduction  uhttps://karger.com/ddi/article-pdf/17/5-6/258/2550239/000016947.pdf  a258–2590 v17